ZIA CP010125 - 10473 (ZIA) | |||
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Title | PHAH and thyroid cancer | ||
Institution | NCI, Bethesda, MD | ||
Principal Investigator | Ward, Mary | NCI Program Director | N/A |
Cancer Activity | N/A | Division | DCEG |
Funded Amount | $17,094 | Project Dates | 03/02/2009 - 00/00/0000 |
Fiscal Year | 2014 | Project Type | Intramural |
Research Topics w/ Percent Relevance | Cancer Types w/ Percent Relevance | ||
Biochemical Epidemiology (45.0%) Cancer (100.0%) Pesticides (20.0%) |
Thyroid (100.0%) | ||
Research Type | |||
Exogenous Factors in the Origin and Cause of Cancer Interactions of Genes and/or Genetic Polymorphisms with Exogenous and/or Endogenous Factors |
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Abstract | |||
Polyhalogenated aromatic hydrocarbons (PHAH) included the polychlorinated biphenyls (PCBs), polybrominated diphenyl ether (PBDE) chemicals, and organochlorine (OC) pesticides. PCBs and most OC pesticides were banned in the 1970s are persistent in the environment. Blood levels of PBDEs, currently used as fire retardents, have increased substantially since the 1980s. PBDEs and other PHAH have demonstrated effects on thyroid hormones but have not been evaluated in relation to thyroid cancer. We plan to evaluate plasma concentrations of PHAH in relation to risk of thyroid cancer using a nested case-control design in the CLUE and PLCO cohorts." |